.img {

Our Projects

Deep Prior Diffraction Tomography

Mar 30, 2020. | By:

Deep Prior Diffraction Tomography


We present a tomographic imaging technique, termed Deep Prior Diffraction Tomography (DP-DT), to reconstruct the 3D refractive index (RI) of thick biological samples at high resolution from a sequence of low-resolution images collected under angularly varying illumination. DP-DT processes the multi-angle data using a phase retrieval algorithm that is extended by a deep image prior (DIP), which reparameterizes the 3D sample reconstruction with an untrained, deep generative 3D convolutional neural network (CNN). We show that DP-DT effectively addresses the missing cone problem, which otherwise degrades the resolution and quality of standard 3D reconstruction algorithms. As DP-DT does not require pre-captured data or pre-training, it is not biased towards any particular dataset. Hence, it is a general technique that can be applied to a wide variety of 3D samples, including scenarios in which large datasets for supervised training would be infeasible or expensive. We applied DP-DT to obtain 3D RI maps of bead phantoms and complex biological specimens, both in simulation and experiment, and show that DP-DT produces higher-quality results than standard regularization techniques. We further demonstrate the generality of DP-DT, using two different scattering models, the first Born and multi-slice models. Our results point to the potential benefits of DP-DT for other 3D imaging modalities, including X-ray computed tomography, magnetic resonance imaging, and electron microscopy.

Click here to learn more

[Read More]


Subscribe to this blog via RSS.


Deeplearning 1

Microscopy 1

Recent Posts

Popular Tags

Deeplearning (1) Microscopy (1)


Deep Prior Diffraction Tomography

Learned Sensing


Our lab focuses at intersection of algorithm, optics and machine learning, Please feel free to reach out if you are interested.

Lab Address

Fitzpatrick Center (CIEMAS) 2569, Duke University
27710, NC,
United States.